Motif ID: STAT5{A,B}.p2

Z-value: 1.003


Transcription factors associated with STAT5{A,B}.p2:

Gene SymbolEntrez IDGene Name
STAT5A 6776 signal transducer and activator of transcription 5A
STAT5B 6777 signal transducer and activator of transcription 5B

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
STAT5Achr17_+_404395640.195.8e-03Click!
STAT5Bchr17_-_404283110.111.1e-01Click!


Activity profile for motif STAT5{A,B}.p2.

activity profile for motif STAT5{A,B}.p2


Sorted Z-values histogram for motif STAT5{A,B}.p2

Sorted Z-values for motif STAT5{A,B}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT5{A,B}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_35168558 12.363 NM_001012320
NM_018443
 ZNF302

zinc finger protein 302

chr11_+_73357222 10.572 NM_001130033
NM_021200
 PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr19_-_37019169 9.635 NM_001012756
NM_001166036
NM_001166037
NM_001166038
 ZNF260



zinc finger protein 260



chr19_+_44576266 9.110 NM_001037813
 ZNF284
zinc finger protein 284
chr5_+_178286913 8.594 NM_058230
 ZNF354B
zinc finger protein 354B
chr7_+_142829169 7.791 NM_002652
 PIP
prolactin-induced protein
chr20_-_43280359 7.717 NM_000022
 ADA
adenosine deaminase
chr20_+_34556528 7.402 NM_001207076
NM_080834
 C20orf152

chromosome 20 open reading frame 152

chr19_+_58095507 7.230 NM_001010879
 ZIK1
zinc finger protein interacting with K protein 1 homolog (mouse)
chr20_-_43280249 7.050 ADA
adenosine deaminase
chr1_+_54519259 6.763 NM_153035
 TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr19_+_37407230 6.713 NM_001204835
NM_001204836
NM_001204837
NM_001204838
NM_001204839
NM_198539
 ZNF568





zinc finger protein 568





chr19_+_44598479 6.623 NM_013398
 ZNF224
zinc finger protein 224
chr15_+_66874506 6.008


chr19_-_58427934 5.920 NM_152475
 ZNF417
zinc finger protein 417
chr19_-_58326280 5.917 NM_024762
 ZNF552
zinc finger protein 552
chr19_+_35225095 5.397 ZNF181
zinc finger protein 181
chrY_+_2709596 5.336 NM_001008
 RPS4Y1
ribosomal protein S4, Y-linked 1
chr19_+_39882018 5.123 MED29
mediator complex subunit 29
chr8_-_56685869 5.037 NM_152417
 TMEM68
transmembrane protein 68
chr9_-_130186491 5.020


chr19_-_57183122 4.897 NM_001005850
 ZNF835
zinc finger protein 835
chr12_+_133656984 4.880 NM_003440
 ZNF140
zinc finger protein 140
chr19_+_44645708 4.879 NM_001144824
NM_006630
 ZNF234

zinc finger protein 234

chr19_+_58281049 4.815 ZNF586
zinc finger protein 586
chrY_+_2709630 4.784 RPS4Y1
ribosomal protein S4, Y-linked 1
chr19_+_58280996 4.742 NM_001077426
NM_001204814
NM_017652
 ZNF586


zinc finger protein 586


chr19_+_54024176 4.682 NM_018555
 ZNF331
zinc finger protein 331
chr19_+_44556163 4.592 NM_013361
 ZNF223
zinc finger protein 223
chr19_+_58361219 4.395 ZNF587
zinc finger protein 587
chr19_-_44809126 4.390 NM_004234
 ZNF235
zinc finger protein 235
chr10_-_131909061 4.142 LOC387723
uncharacterized LOC387723
chr17_+_15603046 4.011 ZNF286A
zinc finger protein 286A
chr19_-_36980758 3.917 ZNF566
zinc finger protein 566
chr19_+_58144510 3.793 NM_006385
NM_198855
 ZNF211

zinc finger protein 211

chr8_+_27631902 3.719 NM_001017420
 ESCO2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr19_+_44617510 3.710 NM_013362
 ZNF225
zinc finger protein 225
chr19_+_44716683 3.685 NM_182490
 ZNF227
zinc finger protein 227
chr22_-_50523853 3.654 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr19_+_39881950 3.587 NM_017592
 MED29
mediator complex subunit 29
chr19_+_44488331 3.464 NM_003445
NM_198089
 ZNF155

zinc finger protein 155

chr19_-_58514136 3.362 ZNF606
zinc finger protein 606
chr19_+_56652689 3.356 ZNF444
zinc finger protein 444
chr16_-_279338 3.301 NM_018032
NM_201412
 LUC7L

LUC7-like (S. cerevisiae)

chr1_-_54519050 3.231 NM_004872
 TMEM59
transmembrane protein 59
chr19_+_56652529 3.220 NM_001253792
NM_018337
 ZNF444

zinc finger protein 444

chr19_+_44529493 3.219 NM_001129996
NM_013360
 ZNF284
ZNF222

zinc finger protein 284
zinc finger protein 222

chr6_-_27440459 3.180 NM_007149
 ZNF184
zinc finger protein 184
chr19_+_40502942 3.177 NM_178544
 ZNF546
zinc finger protein 546
chr20_-_25677173 3.106 NM_015655
 ZNF337
zinc finger protein 337
chr3_+_183903970 3.031 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr9_+_130186652 3.028 NM_007135
 ZNF79
zinc finger protein 79
chr19_+_44507076 2.988 NM_006300
 ZNF230
zinc finger protein 230
chr19_+_35225479 2.945 NM_001029997
NM_001145665
 ZNF181

zinc finger protein 181

chr12_+_133657478 2.936 ZNF140
zinc finger protein 140
chr9_+_104161118 2.928 NM_003452
NM_197977
 ZNF189

zinc finger protein 189

chr10_+_93558068 2.738 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr12_+_133657439 2.722 ZNF140
zinc finger protein 140
chr22_-_50523780 2.710 NM_139202
 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr16_+_53468390 2.695 RBL2
retinoblastoma-like 2 (p130)
chr16_+_53468362 2.691 RBL2
retinoblastoma-like 2 (p130)
chr16_+_53468373 2.660 RBL2
retinoblastoma-like 2 (p130)
chr19_+_58038744 2.648 ZNF549
zinc finger protein 549
chr2_-_63815581 2.646 WDPCP
WD repeat containing planar cell polarity effector
chr19_-_37157718 2.640 NM_153257
 ZNF461
zinc finger protein 461
chr3_+_183903862 2.618 NM_018358
 ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr2_-_27886443 2.583 NM_014860
 SUPT7L
suppressor of Ty 7 (S. cerevisiae)-like
chr9_+_130186714 2.571 ZNF79
zinc finger protein 79
chr22_-_50523737 2.538 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr19_-_36980336 2.493 NM_032838
NM_001145343
NM_001145344
NM_001145345
 ZNF566



zinc finger protein 566



chr1_-_31230673 2.436 NM_006762
 LAPTM5
lysosomal protein transmembrane 5
chr16_+_53468344 2.426 NM_005611
 RBL2
retinoblastoma-like 2 (p130)
chr19_+_58341661 2.419 NM_001204818
 LOC100293516
zinc finger protein
chr10_+_93558139 2.408 NM_025235
 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr8_-_99306563 2.338 NM_024759
 NIPAL2
NIPA-like domain containing 2
chr10_+_93558182 2.247 TNKS2
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
chr3_-_183543295 2.202 NM_024871
 MAP6D1
MAP6 domain containing 1
chr19_+_36209125 2.202 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr19_+_37341259 2.164 NM_003419
 ZNF345
zinc finger protein 345
chr15_+_91643181 2.159 NM_001167580
 SV2B
synaptic vesicle glycoprotein 2B
chr3_+_130745693 2.159 NM_001146003
NM_024800
NM_145910
 NEK11


NIMA (never in mitosis gene a)- related kinase 11


chr6_+_84569394 2.149 CYB5R4
cytochrome b5 reductase 4
chr12_-_133532847 2.120 NM_183238
NM_001164715
 ZNF605

zinc finger protein 605

chr6_+_84569427 2.109 CYB5R4
cytochrome b5 reductase 4
chr1_-_203154304 2.106 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr16_+_53468406 2.082 RBL2
retinoblastoma-like 2 (p130)
chr15_+_42066690 2.080 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr6_+_139094656 2.066 NM_015439
 CCDC28A
coiled-coil domain containing 28A
chr19_+_57946662 2.051 NM_001023561
 ZNF749
zinc finger protein 749
chr18_-_53071225 2.046 NM_001243232
 TCF4
transcription factor 4
chr2_-_241500459 2.030 ANKMY1
ankyrin repeat and MYND domain containing 1
chr6_-_32784727 2.013 NM_002120
 HLA-DOB
major histocompatibility complex, class II, DO beta
chr13_-_99404883 1.957 NM_005073
 SLC15A1
solute carrier family 15 (oligopeptide transporter), member 1
chr4_+_86396251 1.946 NM_001025616
 ARHGAP24
Rho GTPase activating protein 24
chr7_-_108096693 1.933 NM_001193582
NM_001193583
NM_001193584
NM_005010
 NRCAM



neuronal cell adhesion molecule



chr1_-_3773620 1.921 CEP104
centrosomal protein 104kDa
chr13_-_25497054 1.887 NM_018451
 CENPJ
centromere protein J
chr19_+_37341724 1.868 NM_001242472
NM_001242474
 ZNF345

zinc finger protein 345

chr2_+_63816092 1.863 MDH1
malate dehydrogenase 1, NAD (soluble)
chr1_-_109618568 1.853 NM_005645
 TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr22_-_38902315 1.830 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr16_+_53738044 1.791 FTO
fat mass and obesity associated
chr14_+_68286495 1.787 NM_002877
NM_133509
NM_133510
 RAD51B


RAD51 homolog B (S. cerevisiae)


chr19_+_39390570 1.754 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr22_-_38902344 1.715 NM_001098504
NM_006386
 DDX17

DEAD (Asp-Glu-Ala-Asp) box polypeptide 17

chr6_+_84569364 1.700 NM_016230
 CYB5R4
cytochrome b5 reductase 4
chr15_+_91643429 1.699 NM_014848
 SV2B
synaptic vesicle glycoprotein 2B
chr16_-_30103204 1.686 NM_004608
 TBX6
T-box 6
chr19_+_57831824 1.670 NM_213598
 ZNF543
zinc finger protein 543
chr14_-_82000112 1.668 SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr1_-_54518886 1.656 TMEM59
transmembrane protein 59
chr19_+_36208917 1.648 NM_014727
 MLL4
myeloid/lymphoid or mixed-lineage leukemia 4
chr2_+_218989997 1.602 NM_001168298
 CXCR2
chemokine (C-X-C motif) receptor 2
chr16_+_69984809 1.544 NM_182619
 CLEC18C
CLEC18A
C-type lectin domain family 18, member C
C-type lectin domain family 18, member A
chr1_-_54518915 1.524 TMEM59
transmembrane protein 59
chr5_-_111093251 1.502 NM_001142479
NM_001142480
NM_001142478
 C5orf13


chromosome 5 open reading frame 13


chr19_-_45004482 1.494 NM_013256
 ZNF180
zinc finger protein 180
chr19_+_54041332 1.453 NM_001079906
NM_001253798
NM_001253799
 ZNF331


zinc finger protein 331


chr19_-_58220535 1.444 NM_001085384
 ZNF154
zinc finger protein 154
chr11_+_36616039 1.439 NM_138787
 C11orf74
chromosome 11 open reading frame 74
chr1_-_54518790 1.437 TMEM59
transmembrane protein 59
chr2_-_241500167 1.426 ANKMY1
ankyrin repeat and MYND domain containing 1
chr19_+_58038692 1.401 NM_001199295
NM_153263
 ZNF549

zinc finger protein 549

chr19_-_3801809 1.397 NM_002378
 MATK
megakaryocyte-associated tyrosine kinase
chr1_+_119957742 1.338 NM_000198
 HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr14_-_77923888 1.333 NM_001193314
NM_001193315
NM_001193316
NM_001193317
NM_022067
 C14orf133




chromosome 14 open reading frame 133




chr19_-_44860798 1.322 NM_001083335
NM_013380
 ZFP112

zinc finger protein 112 homolog (mouse)

chr8_+_18248754 1.310 NM_000015
 NAT2
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr19_+_44455379 1.303 NM_013359
 ZNF221
zinc finger protein 221
chr2_+_219575684 1.286 TTLL4
tubulin tyrosine ligase-like family, member 4
chr11_-_55703875 1.279 NM_006637
 OR5I1
olfactory receptor, family 5, subfamily I, member 1
chrX_+_149737019 1.278 NM_000252
 MTM1
myotubularin 1
chr2_-_231084600 1.273 NM_004509
NM_004510
NM_080424
 SP110


SP110 nuclear body protein


chr12_-_16759939 1.267 NM_001243613
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_63816143 1.259 NM_001199111
NM_001199112
 MDH1

malate dehydrogenase 1, NAD (soluble)

chr1_+_149871154 1.254 NM_016074
 BOLA1
bolA homolog 1 (E. coli)
chr2_+_172290796 1.251 DCAF17
DDB1 and CUL4 associated factor 17
chr19_-_44439410 1.225 NM_003425
 ZNF45
zinc finger protein 45
chr14_-_82000198 1.225 NM_001244984
NM_005065
 SEL1L

sel-1 suppressor of lin-12-like (C. elegans)

chr19_-_37263653 1.220 NM_001193552
 ZNF850
zinc finger protein 850
chr10_-_62493077 1.204 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr16_-_20338808 1.194 NM_001007240
NM_001007241
NM_001007242
NM_001502
 GP2



glycoprotein 2 (zymogen granule membrane)



chr19_-_37407079 1.180 NM_001037232
 ZNF829
zinc finger protein 829
chr19_+_58111244 1.177 NM_020880
 ZNF530
zinc finger protein 530
chr5_-_177423242 1.170 NM_006261
 PROP1
PROP paired-like homeobox 1
chr7_+_47834888 1.170 NM_025031
 PKD1L1
C7orf69
polycystic kidney disease 1 like 1
chromosome 7 open reading frame 69
chr15_-_83953465 1.144 NM_001717
 BNC1
basonuclin 1
chr22_+_21336616 1.132 LZTR1
leucine-zipper-like transcription regulator 1
chr19_+_58361180 1.123 NM_001204817
NM_032828
 ZNF587

zinc finger protein 587

chr13_-_52378230 1.122 NM_001031719
NM_024705
 DHRS12

dehydrogenase/reductase (SDR family) member 12

chr6_-_116601085 1.111 TSPYL1
TSPY-like 1
chr19_-_38085646 1.087 NM_016536
 ZNF571
zinc finger protein 571
chr11_-_125773086 1.081 NM_031307
 PUS3
pseudouridylate synthase 3
chr18_-_44561967 1.047 NM_016427
 TCEB3B
transcription elongation factor B polypeptide 3B (elongin A2)
chr16_+_15596122 1.045 NM_001142469
 C16orf45
chromosome 16 open reading frame 45
chr9_+_37753803 1.044 RG9MTD3
RNA (guanine-9-) methyltransferase domain containing 3
chr19_+_58987751 1.012 NM_017908
 ZNF446
zinc finger protein 446
chr8_-_146012653 1.003 NM_030580
 ZNF34
zinc finger protein 34
chr1_-_3773760 1.001 NM_014704
 CEP104
centrosomal protein 104kDa
chr16_-_53737713 0.992 NM_001127897
NM_015272
 RPGRIP1L

RPGRIP1-like

chrX_-_139866582 0.963 NM_004065
 CDR1
cerebellar degeneration-related protein 1, 34kDa
chr20_-_33680601 0.957 NM_015638
NM_199368
 TRPC4AP

transient receptor potential cation channel, subfamily C, member 4 associated protein

chr3_-_52864687 0.951 NM_001166449
NM_002218
 ITIH4

inter-alpha-trypsin inhibitor heavy chain family, member 4

chr3_+_122296432 0.951 NM_001113523
 PARP15
poly (ADP-ribose) polymerase family, member 15
chr22_-_38902300 0.947 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr6_+_88182624 0.940 NM_001168398
NM_006416
 SLC35A1

solute carrier family 35 (CMP-sialic acid transporter), member A1

chr19_+_50529211 0.924 NM_001006656
NM_015428
 ZNF473

zinc finger protein 473

chr6_-_32095974 0.914 ATF6B
activating transcription factor 6 beta
chr1_-_31230594 0.908 LAPTM5
lysosomal protein transmembrane 5
chr6_-_159240399 0.881 EZR
ezrin
chrX_+_149737083 0.878 MTM1
myotubularin 1
chr11_+_63137260 0.870 NM_080866
 SLC22A9
solute carrier family 22 (organic anion transporter), member 9
chr19_-_50528683 0.866 NM_001025778
NM_016440
 VRK3

vaccinia related kinase 3

chr1_+_155051263 0.842 NM_004952
 EFNA3
ephrin-A3
chr6_+_88182704 0.842 SLC35A1
solute carrier family 35 (CMP-sialic acid transporter), member A1
chr22_+_37678565 0.841 CYTH4
cytohesin 4
chr22_+_20748397 0.833 NM_003426
 ZNF74
zinc finger protein 74
chr9_+_37753769 0.830 NM_144964
 RG9MTD3
RNA (guanine-9-) methyltransferase domain containing 3
chr5_+_61602065 0.827 KIF2A
kinesin heavy chain member 2A
chr5_-_145562068 0.817 LARS
leucyl-tRNA synthetase
chrX_+_107288199 0.810 NM_001170553
NM_182607
 VSIG1

V-set and immunoglobulin domain containing 1

chr22_-_38902281 0.792 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr19_+_50529276 0.767 ZNF473
zinc finger protein 473
chr19_-_7812396 0.760 NM_001144893
NM_001144894
NM_001144895
NM_001144896
NM_001144897
NM_001144899
NM_021155
 CD209






CD209 molecule






chr7_+_26400503 0.757 NM_001199837
 SNX10
sorting nexin 10
chr12_-_46384346 0.747 SCAF11
SR-related CTD-associated factor 11
chr11_-_72504643 0.741 NM_006645
 STARD10
StAR-related lipid transfer (START) domain containing 10
chr6_-_45345574 0.731 NM_003599
NM_181356
 SUPT3H

suppressor of Ty 3 homolog (S. cerevisiae)

chr9_+_132816197 0.725 GPR107
G protein-coupled receptor 107
chr13_-_25496913 0.724 CENPJ
centromere protein J
chr1_+_3773844 0.714 NM_004402
 DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr1_-_212588235 0.712 TMEM206
transmembrane protein 206
chr11_-_134123138 0.705 NM_001037304
NM_001037305
NM_014174
NM_199297
NM_199298
 THYN1




thymocyte nuclear protein 1




chr13_+_52436116 0.699 NM_031290
 CCDC70
coiled-coil domain containing 70
chr4_+_102734982 0.697 NM_001083907
 BANK1
B-cell scaffold protein with ankyrin repeats 1
chr4_-_16085309 0.691 PROM1
prominin 1
chr12_+_120740123 0.690 NM_012240
 SIRT4
sirtuin 4
chr4_-_16085666 0.689 PROM1
prominin 1
chr22_+_24407870 0.685 CABIN1
calcineurin binding protein 1
chr7_+_2598712 0.674 IQCE
IQ motif containing E

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.61 1.12e-12 GO:0006355 regulation of transcription, DNA-dependent
2.48 2.90e-12 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.44 3.98e-12 GO:0010556 regulation of macromolecule biosynthetic process
2.51 8.88e-12 GO:0051252 regulation of RNA metabolic process
2.27 1.45e-10 GO:0009889 regulation of biosynthetic process
2.31 1.98e-10 GO:0010468 regulation of gene expression
2.27 2.33e-10 GO:0031326 regulation of cellular biosynthetic process
2.20 1.18e-09 GO:0051171 regulation of nitrogen compound metabolic process
2.21 1.97e-09 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.98 1.96e-08 GO:0060255 regulation of macromolecule metabolic process
1.88 2.90e-07 GO:0031323 regulation of cellular metabolic process
1.80 7.42e-07 GO:0019222 regulation of metabolic process
1.84 1.92e-06 GO:0080090 regulation of primary metabolic process
1.38 1.98e-04 GO:0065007 biological regulation
1.37 2.66e-03 GO:0050789 regulation of biological process
1.38 2.82e-03 GO:0050794 regulation of cellular process
2.30 1.81e-02 GO:0032774 RNA biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.56 1.94e-06 GO:0005634 nucleus
1.27 3.42e-04 GO:0043229 intracellular organelle
1.27 3.95e-04 GO:0043226 organelle
1.27 2.90e-03 GO:0043231 intracellular membrane-bounded organelle
1.27 3.12e-03 GO:0043227 membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.53 7.52e-14 GO:0003677 DNA binding
2.59 1.04e-12 GO:0008270 zinc ion binding
2.43 2.94e-12 GO:0046914 transition metal ion binding
1.93 2.07e-08 GO:0003676 nucleic acid binding
1.77 1.78e-07 GO:0043169 cation binding
1.77 2.04e-07 GO:0043167 ion binding
1.77 2.21e-07 GO:0046872 metal ion binding